Pittsburgh Liver Research Center
Our mission is
to enable and promote multidisciplinary research
in all aspects of liver health and disease
for improved clinical outcomes.
Fostering team science
and promoting collaborations across disciplines
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Tumorigenesis
Regenerative Medicine
Chronic Liver Diseases
Special Interest Groups

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Faculty Spotlight: Dr. Gary Thomas

Dr. Thomas’s research investigates molecular pathways that integrate cytoplasmic membrane traffic with the control of nuclear gene expression to maintain cellular homeostasis or drive disease. His team discovered the PACS family of multi-functional sorting proteins, which modulate membrane traffic, ER-mitochondria communication and SIRT1-dependent gene expression. Currently, his lab is using a holistic approach  to investigate, from the atom to the whole-organism, how the PACS proteins function as molecular switches to modulate liver metabolism and how mutations in the PACS genes contribute to obesity and neurodevelopmental diseases.