Pittsburgh Liver Research Center
Our mission is
to enable and promote multidisciplinary research
in all aspects of liver health and disease
for improved clinical outcomes.
Fostering team science
and promoting collaborations across disciplines
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Tumorigenesis
Regenerative Medicine
Chronic Liver Diseases
Special Interest Groups

Upcoming Events

Seminars and events. Know what's coming.

See what's coming

1
May
Liver Seminar - Dr. Seth Karp
12:00pm to 1:00pm

1104 Scaife
7
May
PLRC Seminar Series - Dr. Yasuko Iwakiri
12:00pm to 1:00pm

1104 Scaife
9
May
PLRC Seminar - Dr. Mo Ebrahimkhani
12:00pm to 1:00pm

Eye and Ear Boardroom - 5th floor

Faculty Spotlight - Dr. Prithu Sundd

Dr. Sundd runs an NIH-funded research program within the Vascular Medicine Institute to study the pathophysiology of Sickle Cell Disease (SCD). SCD affects over 3 million people world-wide and results in over 150,000 deaths every year. One of the primary foci of his lab is to identify the role of innate immune pathways in neutrophils and platelets that contribute to organ injury in SCD, using transgenic humanized SCD mice and blood samples from SCD patients. To achieve these goals, his lab has developed real-time intravital microscopy approaches to visualize vascular inflammation in intact organs of live mice. Sickle hepatopathy is an under-diagnosed but a growing complication affecting SCD patients. The current therapy for sickle hepatopathy is primarily supportive and the etiological mechanism is  poorly understood. As a member of the PLRC, Dr. Sundd is collaborating with Paul Monga, MD and Tirthadipa Pradhan-Sundd, PhD in the Division of Experimental Pathology to understand the molecular pathways that promote hepatic complications of SCD.