Faculty Spotlight - Dr. Prithu Sundd
Dr. Sundd runs an NIH-funded research program within the Vascular Medicine Institute to study the pathophysiology of Sickle Cell Disease (SCD). SCD affects over 3 million people world-wide and results in over 150,000 deaths every year. One of the primary foci of his lab is to identify the role of innate immune pathways in neutrophils and platelets that contribute to organ injury in SCD, using transgenic humanized SCD mice and blood samples from SCD patients. To achieve these goals, his lab has developed real-time intravital microscopy approaches to visualize vascular inflammation in intact organs of live mice. Sickle hepatopathy is an under-diagnosed but a growing complication affecting SCD patients. The current therapy for sickle hepatopathy is primarily supportive and the etiological mechanism is poorly understood. As a member of the PLRC, Dr. Sundd is collaborating with Paul Monga, MD and Tirthadipa Pradhan-Sundd, PhD in the Division of Experimental Pathology to understand the molecular pathways that promote hepatic complications of SCD.