Eric Goetzman, PhD*

Eric Goetzman

Eric Goetzman, PhD*

Appointments/Affiliations: 

Assistant Professor
Department of Pediatrics

Rangos 5117
4401 Penn Avenue
Pittsburgh, PA 15224


Liver-Related Work

Research Interests: My area of expertise is in liver energy metabolism and the fatty acid oxidation pathway in particular. My laboratory utilizes substrate flux assays (radiolabeled substrates), Oroboros high-resolution respirometry, and various biochemical assays to study hepatic mitochondrial function in mouse models.
 
Ongoing Research Studies:
  1. Role of sirtuin deacylases in regulating the mitochondrial fatty acid oxidation (FAO) pathway (NIH-funded). We are using a combination of in vitro and in vivo approaches to identify key lysine post-translational modifications on mitochondrial enzymes. A particular focus is on how lysine modifications may alter the assembly of large metabolic protein super-complexes in the mitochondria.
  2. Co-investigator with Dr. Ed Prochownik on an NIH-funded project investigating the role of C-Myc in regulating metabolism during liver tumorigenesis.
  3. Role of sirtuins in maintaining the function of peroxisomes during aging and tumorigenesis in the liver. This is a pilot project—in collaboration with Donna Stolz of the Center for Biologic Imaging—that was recently funded by the UPMC aging research group “Stimulating Pittsburgh Research in Geroscience (SPRIG).”

 

 

Special Interest Groups: 
Chronic Liver Injury
Liver Tumorigenesis